A Difference A Day Makes | [s5e22] What

: Creator Shonda Rhimes noted that Denny's appearance in this episode was meant to represent "Death," which is why he wore black and spoke sparingly compared to previous appearances.

: To promote the 100th episode, ABC created a real wedding website for Meredith and Derek that fans could actually visit and RSVP to. [S5E22] What a Difference a Day Makes

: Jeffrey Dean Morgan makes a final appearance as Denny Duquette, appearing as a hallucination to Izzie that Derek and Bailey eventually realize is a symptom of her worsening condition. Behind the Scenes Facts : Creator Shonda Rhimes noted that Denny's appearance

: Despite the shift in plans, the wedding remains a fan favorite, featuring the original "MAGIC" interns (Meredith, Alex, George, Izzie, and Cristina) as the wedding party. Behind the Scenes Facts : Despite the shift

: Rhimes described the episode as the moment Meredith evolved from a "dark and twisty" girl into an "extraordinary" woman capable of choosing happiness.

: After Derek and Bailey discover that Izzie has an inoperable brain tumor, the group decides to celebrate her life and love immediately.