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Lack of functional otoferlin or its C2 domain interaction prevents proper vesicle docking, leading to profound deafness. Summary Table: Otoferlin C2 Interactions Function/Location C2B-C2G Main interface for membrane binding C2D Crucial Ca 2+raised to the 2 plus power binding site; mutations affect sound encoding C2F-C2G Rearrange upon membrane binding to close structure Target Membrane Membrane where vesicles are docked

The study highlights that membrane binding involves a cooperative effort of multiple domains. tm,cc,jp

Structure and function of otoferlin, a synaptic protein of ... - PMC Lack of functional otoferlin or its C2 domain

Based on the 2025 research regarding the protein , which is crucial for hearing and synaptic transmission, - PMC Based on the 2025 research regarding

Binding Sites: High-resolution structures revealed that multiple Ca 2+raised to the 2 plus power

The binding requires cooperation between multiple C2 domains to secure the vesicle to the target membrane.