The film features a high-profile ensemble cast, though many critics felt their talents were underutilised:

as Johanna Mortdecai: Charlie's posh and clever wife who often stays one step ahead of him.

Some praise was reserved for the film's visual elements, including the lush production design by James Merifield and costumes by Ruth Myers, which captured a sense of "gauche grandeur".

The story follows (Depp), a debonair yet unscrupulous art dealer and part-time rogue who is deeply in debt to the British government. To settle his tax bills, he is recruited by Inspector Alistair Martland (Ewan McGregor) of MI5 to recover a stolen Goya painting. Rumour has it that the painting contains a hidden code leading to a lost bank account filled with Nazi gold.

as Jock Strapp: Mortdecai's resilient manservant who repeatedly survives accidental injuries inflicted by his master.

as Milton Krampf: A sleazy American art dealer pursuing the same Goya painting. Critical and Commercial Performance