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: The active ingredient in Benadryl , ZzzQuil , and Sominex . It is a first-generation antihistamine that causes significant sleepiness within about an hour.

: Found in Unisom SleepTabs and NyQuil. This antihistamine tends to stay in the system longer than diphenhydramine, which may lead to a "hangover" feeling the next morning. Natural and Herbal Sedatives legal sedatives buy

These medications are regulated by the FDA and are often used as "nighttime sleep aids" because their primary side effect is drowsiness. : The active ingredient in Benadryl , ZzzQuil , and Sominex