Hem#265 — Rar

The chimeric receptor provides a dramatic and easily monitored visual indicator of RAR ligand presence in the cellular environment.

The chimera is constructed by fusing the ligand-binding domain of the retinoic acid receptor (RAR) to a reporter sequence that allows tracking (e.g., green fluorescent protein). Hem#265 rar

This paper highlights a novel method that combines the ligand-binding domain (LBD) of RAR with the trafficking machinery of the GR, creating a chimeric receptor that moves from the cytoplasm to the nucleus upon ligand binding. 2. Methodology: Design of the GR-RAR Chimera The chimeric receptor provides a dramatic and easily

Development and Application of a Glucocorticoid/Retinoic Acid Receptor (GR-RAR) Chimera for In Vivo Translocation Assays Hem#265 rar