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: The role of Regulatory T cells (Tregs) in the gastrointestinal tract is a major area of study for inhibiting systemic inflammation associated with GvHD.

: Recent studies focus on identifying risk factors like HSCT-TMA (Thrombotic Microangiopathy), which can exacerbate GvHD symptoms. Modern treatment strategies emphasize early detection through organ biopsies and staining for markers like C4d and C5b-9 [5, 8].

: For patients with GvHD-related complications, treatments such as Eculizumab are being used to inhibit the C5 complement pathway, though this requires careful monitoring for infections like Neisseria meningitidis . Technical Context (Digital Files)