In cases associated with HCV infection, antiviral therapy can lead to lymphoma regression. 6. Conclusion
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Characterized by a diffuse infiltration of the splenic red pulp and a specific immunophenotype ( In cases associated with HCV infection, antiviral therapy
is a frequent cytogenetic abnormality found in approximately 40% of SMZL cases. 4. Clinical Presentation and Complications In cases associated with HCV infection
Splenic lymphomas represent a heterogeneous group of rare B-cell neoplasms primarily involving the spleen, bone marrow, and often the peripheral blood. The most common subtype is Splenic Marginal Zone Lymphoma (SMZL). This paper reviews the clinical presentation, diagnostic criteria (histology and immunophenotype), and evolving therapeutic strategies for these malignancies. 1. Introduction
Anemia or thrombocytopenia due to hypersplenism or bone marrow involvement.