: Associated JAKs transphosphorylate and activate each other.
: Activated JAKs phosphorylate the receptor tail, creating docking sites. Download Les inhibiteurs JAK STAT pdf
: STAT dimers translocate to the nucleus to regulate gene expression. Basic Mechanisms of JAK Inhibition - PMC - NIH : Associated JAKs transphosphorylate and activate each other
: Phosphorylated STATs dissociate and form dimers. Download Les inhibiteurs JAK STAT pdf