Diseases - Mr | Validity

: There are no common causes (confounders) shared between the genetic variants and the outcome.

MR uses genetic variants as "natural experiments" to determine if an exposure (like high blood pressure) truly causes a disease (like stroke), rather than just being associated with it. ⚖️ The Three Pillars of MR Validity Diseases - Mr Validity

: Uses summary statistics from two separate groups (e.g., one group for LDL levels and another for heart disease data), which is often more cost-effective. : There are no common causes (confounders) shared

For an MR report to be considered valid, it must demonstrate that the genetic instruments (SNPs) meet these criteria: and mortality data.

: A Bayesian meta-regression tool used by the Global Burden of Disease Study to ensure consistency between disease incidence, prevalence, and mortality data.