Try running the game in Windowed Mode or use a "Borderless Window" tool if the game crashes when Alt-Tabbing or during cinematic-to-dialogue transitions. Known Game Glitches Left dialogue crashes - Deus Ex: Human Revolution
If the game crashes on launch or during scene transitions, try unticking DirectX 11 in the game's launcher settings. Deus ex human revolution dialogue crash fix
Modern CPUs with many cores can cause the game to fail immediately or during heavy processing tasks. Try running the game in Windowed Mode or
Open Windows Sound Settings ( mmsys.cpl ) and disable all unused playback devices. Deus ex human revolution dialogue crash fix